The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private-public partnership between the UK Biobank (UKB) and eight biopharmaceutical corporations that may full the sequencing of exomes for all ~500,000 UKB members. Here, we describe the early outcomes from ~200,000 UKB members and the options of this mission that enabled its success. The biopharmaceutical trade has more and more used human genetics to enhance success in drug discovery.
Recognizing the want for large-scale human genetics information, in addition to the distinctive worth of the information entry and contribution phrases of the UKB, the UKB-ESC was fashioned. As a end result, exome information from 200,643 UKB enrollees at the moment are accessible. These information embrace ~10 million exonic variants-a wealthy useful resource of uncommon coding variation that’s notably precious for drug discovery.
The UKB-ESC precompetitive collaboration has additional strengthened tutorial and trade ties and has offered groups with a possibility to work together with and be taught from the wider research neighborhood.
Association of pre-pandemic high-density lipoprotein ldl cholesterol with danger of COVID-19 hospitalisation and demise: The UK Biobank cohort examine
There is rising proof of, and organic plausibility for, elevated ranges of high-density lipoprotein ldl cholesterol (HDL-C) being associated to decrease charges of respiratory illness. We examined whether or not pre-pandemic HDL-C inside the regular vary is related to subsequent COVID-19 hospitalisations and demise. We analysed information on members from UK Biobank, a potential cohort examine, baseline information for which had been collected between 2006 and 2010.
Follow-up for COVID-19 was through hospitalisation data (1845 occasions in 317,306 people) and a nationwide mortality registry (458 deaths in 317,833 people). After controlling for a sequence of confounding elements which included well being behaviours, inflammatory markers, and socio-economic standing, greater ranges of HDL-C had been associated to a decrease danger of later hospitalisation.
The impact was linear (p-value for pattern 0.001), whereby a 0.2 mmol/L enhance in HDL-C was related to a 7% decrease danger (odds ratio; 95% confidence interval: 0.93; 0.90, 0.96). Corresponding relationships for mortality had been markedly weaker, such that statistical significance at standard ranges weren’t obvious for each the linear pattern (p-value 0.25) and the odds ratio per 0.2 mmol/L enhance (0.98; 0.91, 1.05).
While our discovering for HDL-C and hospitalisations for COVID-19 increase the risk that beneficial modification of this ldl cholesterol fraction through life-style modifications or drug intervention could influence upon the danger of the illness, it warrants testing in different research.
Privacy in breast most cancers biobank: Chinese sufferers’ perceptions
Drawing on 40 in-depth interviews with Chinese breast most cancers sufferers who participated in the breast most cancers biobank at a hospital in Beijing, China, this paper explores these sufferers’ perceptions of privateness. The evaluation signifies that these sufferers primarily perceived privateness as informational privateness; they had been involved about the disclosure of contact data, most cancers analysis, and genetic testing outcomes; additional, their views on disclosing completely different varieties of private data had been dynamic and heterogeneous in numerous relationships and contexts, which differs from the stereotypical beliefs of privateness in China.
This paper offers located understanding of why these sufferers had such privateness perceptions and what methods they adopted to deal with their privateness. It then discusses the worldwide similarities and variations in the disclosure of most cancers and genetic testing outcomes.
Establishment of biobank facility at Endocrinology and Metabolism Research Institute of Iran: experiences, challenges, and future outlook
Biobanking as an rising process referring to the growth of pattern storage applied sciences which offer important constructions for conducting research. This paper presents the experiences and challenges confronted whereas establishing the non-communicable ailments (NCDs)-dedicated biobank at Endocrinology and Metabolism Research Institute (EMRI) in Iran, resembling infrastructure, Laboratory Information Management System (LIMS), moral and authorized points, pattern assortment, preservation, and high quality management (QC). NCDs are a significant well being downside round the world and in Iran, which is entry to organic samples are required to understanding and planning to those ailments.
The predominant targets of the EMRI biobank is at present the assortment and storage of organic samples resembling blood, serum, plasma, urine and DNA from sufferers with NCDs together with diabetes mellitus osteoporosis and aged inhabitants primarily based on cohort and cross-sectional research. The biobank of EMRI goals to have a significant influence on the NCDs by supplying organic samples for nationwide and worldwide research initiatives.
Building Research Support Capacity throughout Human Health Biobanks throughout the COVID-19 Pandemic
Human well being biobanks are varieties of research infrastructure that offer biospecimens and related information to researchers, and subsequently juxtapose the actions of scientific care and biomedical research. The self-discipline of biobanking has existed for over 20 years and is supported by a number of worldwide skilled societies and devoted tutorial journals. However, regardless of each rising research demand for human biospecimens, and the development of biobanking as an instructional self-discipline, many particular person biobanks proceed to expertise sustainability challenges.
This commentary will summarize how the COVID-19 pandemic is creating new challenges and alternatives for each the well being biobanking sector and the supporting self-discipline of biobanking. While the challenges for biobanks could also be quite a few and acute, there are alternatives for each particular person biobanks and the self-discipline of biobanking to embrace change such that biobanks can proceed to assist and drive biomedical research.
Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified |
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| 20005-1-FC-B | Alpha Diagnostics | 0.1 mg | 225 EUR |
Rat IgG (Fc)-FITC Conjuagte (isotype control), purified |
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| 20005-1-FC-F | Alpha Diagnostics | 0.1 mg | 225 EUR |
Rat IgG (Fc)-HRP Conjuagte (isotype control), purified |
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| 20005-1-FC-HP | Alpha Diagnostics | 0.1 mg | 225 EUR |
Human IgG (Fc) fragment, purified (>95%, low endotoxin) |
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| 20007-1-FC-LE | Alpha Diagnostics | 100 ul | 225 EUR |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
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| VAng-1452Lsx-200g | Creative Biolabs | 200 µg | 3844 EUR |
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Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1) |
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Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
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| VAng-1452Lsx-25g | Creative Biolabs | 25 µg | 1013 EUR |
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Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1) |
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Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative |
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| 7615-Fc | Alpha Diagnostics | 1 kit | 712 EUR |
Horse IgG-Fc ELISA Kit, 96 tests, Quantitative |
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| 7715-Fc | Alpha Diagnostics | 1 kit | 712 EUR |
Dog IgG (Fc) fragment (isotype control, non-immune), purified |
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| 20016-FC | Alpha Diagnostics | 0.5 mg | 250 EUR |
Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified |
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| 20007-1-Fc-B | Alpha Diagnostics | 0.1 mg | 164 EUR |
Human IgG Fc-FITC conjugate (isotype control, non-immune), purified |
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| 20007-1-Fc-F | Alpha Diagnostics | 0.1 mg | 164 EUR |
Human IgG Fc-HRP conjugate (isotype control, non-immune), purified |
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| 20007-1-Fc-HP | Alpha Diagnostics | 0.1 mg | 164 EUR |
Dkk-1 Polyclonal Antibody |
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| ES4292-100ul | ELK Biotech | 100ul | 279 EUR |
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Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Dkk-1 Polyclonal Antibody |
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| ES4292-50ul | ELK Biotech | 50ul | 207 EUR |
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Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Dkk-1 Polyclonal Antibody |
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| ABP53293-003ml | Abbkine | 0.03ml | 158 EUR |
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Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
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Dkk-1 Polyclonal Antibody |
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| ABP53293-01ml | Abbkine | 0.1ml | 289 EUR |
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Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
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Dkk-1 Polyclonal Antibody |
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| ABP53293-02ml | Abbkine | 0.2ml | 414 EUR |
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Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
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Anti-Dkk-1 antibody |
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| STJ97257 | St John's Laboratory | 200 µl | 197 EUR |
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Description: Rabbit polyclonal to Dkk-1. |
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Anti-Dkk-1 antibody |
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| STJ98000 | St John's Laboratory | 100 µl | 234 EUR |
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Description: Mouse monoclonal to Dkk-1. |
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Dkk-1 Polyclonal Antibody |
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| 41928-50ul | SAB | 50ul | 187 EUR |
Dkk-1 Polyclonal Antibody |
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| 41928-100ul | SAB | 100ul | 252 EUR |
DKK-1 Recombinant Protein |
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| 40-225-0002mg | ProSci | 0.002 mg | 259.25 EUR |
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Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
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DKK-1 Recombinant Protein |
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| 40-225-001mg | ProSci | 0.01 mg | 364.25 EUR |
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Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
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DKK 1 Recombinant Protein |
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| 96-236 | ProSci | 0.1 mg | 626.75 EUR |
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Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression. |
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DKK 1 Recombinant Protein |
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| 96-237 | ProSci | 0.025 mg | 516.5 EUR |
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Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression. |
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Dkk-1 Recombinant Protein |
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| 96-861 | ProSci | 0.1 mg | 542.75 EUR |
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Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression. |
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Dkk-1 Recombinant Protein |
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| 96-990 | ProSci | 0.05 mg | 595.25 EUR |
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Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression. |
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IGF-1-Fc |
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| E13-m003-1 | EnoGene | 10μg | 291 EUR |
Dkk-2 |
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| GT15222 | Neuromics | 100 ug | 526 EUR |
Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin) |
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| 20009-1-R-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin) |
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| 20007-1-FC-LE-B | Alpha Diagnostics | 25 ug | 286 EUR |
Goat IgG (fc)-Biotin conjugate (isotype control) |
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| 20011-Fc-B | Alpha Diagnostics | 100 ug | 164 EUR |
Goat IgG (fc)-FITC conjugate (isotype control) |
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| 20011-Fc-F | Alpha Diagnostics | 100 ug | 164 EUR |
Goat IgG (fc)-HRP conjugate (isotype control) |
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| 20011-Fc-HP | Alpha Diagnostics | 100 ug | 164 EUR |
DKK-1 (CHO-expressed), Mouse |
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| HY-P7154 | MedChemExpress | 50ug | 762 EUR |
DKK-1 (HEK293-expressed), Human |
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| HY-P7155A | MedChemExpress | 50ug | 843 EUR |
Recombinant Human DKK-1 Protein |
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| PROTO94907-3 | BosterBio | 10ug | 317 EUR |
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Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
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Recombinant Mouse Dkk-1 Protein |
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| RP01062 | Abclonal | 5 μg | 183 EUR |
Dkk-1 Polyclonal Conjugated Antibody |
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| C41928 | SAB | 100ul | 397 EUR |
DKK-1 ELISA KIT|Human |
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| EF000090 | Lifescience Market | 96 Tests | 689 EUR |
Human DKK-1 ELISA kit |
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| LF-EK50797 | Abfrontier | 1×96T | 648 EUR |
FC 131 |
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| B7647-1 | ApexBio | 1 mg | 187 EUR |
Dkk-3 antibody |
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| 22898-100ul | SAB | 100ul | 390 EUR |
Dog IgG (Fc) fragment (isotype control, non-immune), purified |
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| 20016-3-FC | Alpha Diagnostics | 0.5 mg | 250 EUR |
OPG-Fc Osteoprotegerin Human Recombinant Protein /Fc Chimera |
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| PROTO00300-1 | BosterBio | Regular: 50ug | 317 EUR |
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Description: Recombinant OPG produced in yeast contains 2x412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 109.6kDa. |
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Human DKK-1 PicoKine ELISA Kit |
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| EK0867 | BosterBio | 96 wells | 425 EUR |
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Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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ELISA kit for Human DKK-1 |
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| EK5390 | SAB | 96 tests | 553 EUR |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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ELISA kit for Rat DKK-1 |
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| EK5668 | SAB | 96 tests | 553 EUR |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Human CellExp? DKK-1, Human Recombinant |
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| 7132-10 | Biovision | 278 EUR | |
Human CellExp? DKK-1, Human Recombinant |
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| 7132-50 | Biovision | 1132 EUR | |
Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified |
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| 20016-FC-B | Alpha Diagnostics | 0.1 mg | 225 EUR |
Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified |
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| 20016-FC-F | Alpha Diagnostics | 0.1 mg | 225 EUR |
Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified |
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| 20016-FC-HP | Alpha Diagnostics | 0.1 mg | 225 EUR |
SCF-Fc |
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| E13-m004-1 | EnoGene | 10μg | 343 EUR |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
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| CC49-10ug | Novoprotein | 10ug | 156 EUR |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
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Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
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| CC49-1mg | Novoprotein | 1mg | 2283 EUR |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
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Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
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| CC49-500ug | Novoprotein | 500ug | 1613 EUR |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
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Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
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| CC49-50ug | Novoprotein | 50ug | 369 EUR |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
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Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin) |
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| 20007-G3-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Dkk-3 Polyclonal Antibody |
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| ES5541-50ul | ELK Biotech | 50ul | 207 EUR |
|
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Dkk-3 Polyclonal Antibody |
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| ES5541-100ul | ELK Biotech | 100ul | 279 EUR |
|
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Dkk-3 Polyclonal Antibody |
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| ABP54542-003ml | Abbkine | 0.03ml | 158 EUR |
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
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Dkk-3 Polyclonal Antibody |
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| ABP54542-01ml | Abbkine | 0.1ml | 289 EUR |
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
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Dkk-3 Polyclonal Antibody |
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| ABP54542-02ml | Abbkine | 0.2ml | 414 EUR |
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
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Anti-Dkk-3 antibody |
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| STJ92720 | St John's Laboratory | 200 µl | 197 EUR |
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Description: Rabbit polyclonal to Dkk-3. |
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Anti-Dkk-3 antibody |
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| STJ98001 | St John's Laboratory | 100 µl | 234 EUR |
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Description: Mouse monoclonal to Dkk-3. |
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DKK 3 Recombinant Protein |
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| 96-239 | ProSci | 0.2 mg | 684.5 EUR |
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Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported. |
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Dkk-3 Recombinant Protein |
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| 96-991 | ProSci | 0.05 mg | 542.75 EUR |
|
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported. |
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DKK-2 Recombinant Protein |
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| 40-651 | ProSci | 2 ug | 259.25 EUR |
|
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions. |
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DKK-3 Recombinant Protein |
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| 40-652 | ProSci | 2 ug | 259.25 EUR |
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Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions. |
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Human DKK-1 ELISA kit (4×96T) |
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| LF-EK50798 | Abfrontier | 4×96T | 2201 EUR |
SDF-1α-Fc |
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| E13-m001-1 | EnoGene | 10μg | 291 EUR |
VEGF-121-Fc |
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| E13-m005-1 | EnoGene | 10μg | 343 EUR |
VEGF-165-Fc |
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| E13-m006-1 | EnoGene | 10μg | 343 EUR |
IL-2-Fc |
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| E13-m007-1 | EnoGene | 10μg | 310 EUR |
Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin) |
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| 20007-G1-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin) |
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| 20007-G2-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin) |
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| 20007-G4-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Recombinant (HEK) Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin) |
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| 20102-102-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Recombinant (HEK) Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin) |
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| 20102-103-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Recombinant (HEK) Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin) |
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| 20102-104-FC | Alpha Diagnostics | 50 ug | 286 EUR |
Recombinant Human CD47 Protein, His-Fc (IgG), Insect-10ug |
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| QP11336-HIS-Fc-10ug | EnQuireBio | 10ug | 201 EUR |
PinPoint-FC attP Placement Vector |
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| PIN300A-1 | SBI | 10ug | 778 EUR |
Recombinant (HEK) Mouse IgG1-Fc (98-321aa, 102Cys/Ser, ~32 kda, His-tag, >95%, low endotoxin) |
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| 20102-101-FC | Alpha Diagnostics | 50 | 286 EUR |
FLT4-Fc Vascular Endothelial Growth Factor Receptor-3 Fc Chimera Human Recombinant Protein |
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| PROTP35916-1 | BosterBio | Regular: 10ug | 317 EUR |
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Description: Soluble FLT4 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a monomeric, glycosylated, polypeptide containing 774 amino acids and having a molecular mass of 260 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.;The FLT4 Fc Chimera is purified by proprietary chromatographic techniques. |
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Human DKK-1(Dickkopf-related protein 1) ELISA Kit |
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| EH0113 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Recombinant Human Dkk-3 Protein |
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| RP00355 | Abclonal | 10 μg | 164 EUR |
DKK-3 ELISA KIT|Human |
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| EF000091 | Lifescience Market | 96 Tests | 689 EUR |
Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221) |
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| OKAG00221 | Aviva Systems Biology | 96 Wells | 596 EUR |
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Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL |
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TNFRSF14 HVEM-Fc Human Recombinant Protein |
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| PROTO43557-1 | BosterBio | Regular: 100ug | 317 EUR |
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Description: TNFRSF14 Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide chain containing 396 amino acids and having a molecular mass of 58.0kDa. |
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Recombinant Human FGFR1a (IIIc) Fc Protein |
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| PROTP11362-1 | BosterBio | 50ug | 317 EUR |
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Description: The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous multiple forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant human FGFR1a (IIIc) is a 65.2 kDa protein containing 586 amino acids. Under reducing conditions, FGFR1a migrates between 100-110 kDa on SDS-PAGE gel. |
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Human EPOR / Erythropoietin Receptor Protein (Fc Tag) |
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| G1011-.1 | ApexBio | 100 µg | 696 EUR |
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