The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private-public partnership between the UK Biobank (UKB) and eight biopharmaceutical corporations that may full the sequencing of exomes for all ~500,000 UKB members. Here, we describe the early outcomes from ~200,000 UKB members and the options of this mission that enabled its success. The biopharmaceutical trade has more and more used human genetics to enhance success in drug discovery.
Recognizing the want for large-scale human genetics information, in addition to the distinctive worth of the information entry and contribution phrases of the UKB, the UKB-ESC was fashioned. As a end result, exome information from 200,643 UKB enrollees at the moment are accessible. These information embrace ~10 million exonic variants-a wealthy useful resource of uncommon coding variation that’s notably precious for drug discovery.
The UKB-ESC precompetitive collaboration has additional strengthened tutorial and trade ties and has offered groups with a possibility to work together with and be taught from the wider research neighborhood.
Association of pre-pandemic high-density lipoprotein ldl cholesterol with danger of COVID-19 hospitalisation and demise: The UK Biobank cohort examine
There is rising proof of, and organic plausibility for, elevated ranges of high-density lipoprotein ldl cholesterol (HDL-C) being associated to decrease charges of respiratory illness. We examined whether or not pre-pandemic HDL-C inside the regular vary is related to subsequent COVID-19 hospitalisations and demise. We analysed information on members from UK Biobank, a potential cohort examine, baseline information for which had been collected between 2006 and 2010.
Follow-up for COVID-19 was through hospitalisation data (1845 occasions in 317,306 people) and a nationwide mortality registry (458 deaths in 317,833 people). After controlling for a sequence of confounding elements which included well being behaviours, inflammatory markers, and socio-economic standing, greater ranges of HDL-C had been associated to a decrease danger of later hospitalisation.
The impact was linear (p-value for pattern 0.001), whereby a 0.2 mmol/L enhance in HDL-C was related to a 7% decrease danger (odds ratio; 95% confidence interval: 0.93; 0.90, 0.96). Corresponding relationships for mortality had been markedly weaker, such that statistical significance at standard ranges weren’t obvious for each the linear pattern (p-value 0.25) and the odds ratio per 0.2 mmol/L enhance (0.98; 0.91, 1.05).
While our discovering for HDL-C and hospitalisations for COVID-19 increase the risk that beneficial modification of this ldl cholesterol fraction through life-style modifications or drug intervention could influence upon the danger of the illness, it warrants testing in different research.
Privacy in breast most cancers biobank: Chinese sufferers’ perceptions
Drawing on 40 in-depth interviews with Chinese breast most cancers sufferers who participated in the breast most cancers biobank at a hospital in Beijing, China, this paper explores these sufferers’ perceptions of privateness. The evaluation signifies that these sufferers primarily perceived privateness as informational privateness; they had been involved about the disclosure of contact data, most cancers analysis, and genetic testing outcomes; additional, their views on disclosing completely different varieties of private data had been dynamic and heterogeneous in numerous relationships and contexts, which differs from the stereotypical beliefs of privateness in China.
This paper offers located understanding of why these sufferers had such privateness perceptions and what methods they adopted to deal with their privateness. It then discusses the worldwide similarities and variations in the disclosure of most cancers and genetic testing outcomes.
Establishment of biobank facility at Endocrinology and Metabolism Research Institute of Iran: experiences, challenges, and future outlook
Biobanking as an rising process referring to the growth of pattern storage applied sciences which offer important constructions for conducting research. This paper presents the experiences and challenges confronted whereas establishing the non-communicable ailments (NCDs)-dedicated biobank at Endocrinology and Metabolism Research Institute (EMRI) in Iran, resembling infrastructure, Laboratory Information Management System (LIMS), moral and authorized points, pattern assortment, preservation, and high quality management (QC). NCDs are a significant well being downside round the world and in Iran, which is entry to organic samples are required to understanding and planning to those ailments.
The predominant targets of the EMRI biobank is at present the assortment and storage of organic samples resembling blood, serum, plasma, urine and DNA from sufferers with NCDs together with diabetes mellitus osteoporosis and aged inhabitants primarily based on cohort and cross-sectional research. The biobank of EMRI goals to have a significant influence on the NCDs by supplying organic samples for nationwide and worldwide research initiatives.
Building Research Support Capacity throughout Human Health Biobanks throughout the COVID-19 Pandemic
Human well being biobanks are varieties of research infrastructure that offer biospecimens and related information to researchers, and subsequently juxtapose the actions of scientific care and biomedical research. The self-discipline of biobanking has existed for over 20 years and is supported by a number of worldwide skilled societies and devoted tutorial journals. However, regardless of each rising research demand for human biospecimens, and the development of biobanking as an instructional self-discipline, many particular person biobanks proceed to expertise sustainability challenges.
This commentary will summarize how the COVID-19 pandemic is creating new challenges and alternatives for each the well being biobanking sector and the supporting self-discipline of biobanking. While the challenges for biobanks could also be quite a few and acute, there are alternatives for each particular person biobanks and the self-discipline of biobanking to embrace change such that biobanks can proceed to assist and drive biomedical research.
-Biotin Conjuagte (isotype control), purified) Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified |
|
20005-1-FC-B |
Alpha Diagnostics |
0.1 mg |
EUR 225 |
-FITC Conjuagte (isotype control), purified) Rat IgG (Fc)-FITC Conjuagte (isotype control), purified |
|
20005-1-FC-F |
Alpha Diagnostics |
0.1 mg |
EUR 225 |
-HRP Conjuagte (isotype control), purified) Rat IgG (Fc)-HRP Conjuagte (isotype control), purified |
|
20005-1-FC-HP |
Alpha Diagnostics |
0.1 mg |
EUR 225 |
 fragment, purified (>95%, low endotoxin)) Human IgG (Fc) fragment, purified (>95%, low endotoxin) |
|
20007-1-FC-LE |
Alpha Diagnostics |
100 ul |
EUR 225 |
 [Fc] [Avi]) Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
|
VAng-1452Lsx-200g |
Creative Biolabs |
200 µg |
EUR 3844 |
|
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1) |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
|
VAng-1452Lsx-25g |
Creative Biolabs |
25 µg |
EUR 1013 |
|
Description: Biotinylated Human Dkk-1, Fc tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: O94907-1) |
 Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative |
|
7615-Fc |
Alpha Diagnostics |
1 kit |
EUR 712 |
 Horse IgG-Fc ELISA Kit, 96 tests, Quantitative |
|
7715-Fc |
Alpha Diagnostics |
1 kit |
EUR 712 |
 fragment (isotype control, non-immune), purified) Dog IgG (Fc) fragment (isotype control, non-immune), purified |
|
20016-FC |
Alpha Diagnostics |
0.5 mg |
EUR 250 |
, purified) Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified |
|
20007-1-Fc-B |
Alpha Diagnostics |
0.1 mg |
EUR 164 |
, purified) Human IgG Fc-FITC conjugate (isotype control, non-immune), purified |
|
20007-1-Fc-F |
Alpha Diagnostics |
0.1 mg |
EUR 164 |
, purified) Human IgG Fc-HRP conjugate (isotype control, non-immune), purified |
|
20007-1-Fc-HP |
Alpha Diagnostics |
0.1 mg |
EUR 164 |
 Dkk-1 Polyclonal Antibody |
|
41928-100ul |
SAB |
100ul |
EUR 252 |
Dkk-1 Polyclonal Antibody |
|
41928-50ul |
SAB |
50ul |
EUR 187 |
Dkk-1 Polyclonal Antibody |
|
ABP53293-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
Dkk-1 Polyclonal Antibody |
|
ABP53293-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
Dkk-1 Polyclonal Antibody |
|
ABP53293-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1 |
Dkk-1 Polyclonal Antibody |
|
ES4292-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Dkk-1 Polyclonal Antibody |
|
ES4292-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
 Anti-Dkk-1 antibody |
|
STJ97257 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Dkk-1. |
Anti-Dkk-1 antibody |
|
STJ98000 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Dkk-1. |
 IGF-1-Fc |
|
E13-m003-1 |
EnoGene |
10μg |
EUR 291 |
 Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin)) Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin) |
|
20009-1-R-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 fragment-Biotin purified (>95%, low endotoxin)) Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin) |
|
20007-1-FC-LE-B |
Alpha Diagnostics |
25 ug |
EUR 286 |
 Dkk-1 Polyclonal Conjugated Antibody |
|
C41928 |
SAB |
100ul |
EUR 397 |
 Human DKK-1 ELISA kit |
|
LF-EK50797 |
Abfrontier |
1×96T |
EUR 648 |
 Recombinant Human DKK-1 Protein |
|
PROTO94907-3 |
BosterBio |
10ug |
EUR 317 |
|
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. |
 Recombinant Mouse Dkk-1 Protein |
|
RP01062 |
Abclonal |
5 μg |
EUR 183 |
-Biotin conjugate (isotype control)) Goat IgG (fc)-Biotin conjugate (isotype control) |
|
20011-Fc-B |
Alpha Diagnostics |
100 ug |
EUR 164 |
-FITC conjugate (isotype control)) Goat IgG (fc)-FITC conjugate (isotype control) |
|
20011-Fc-F |
Alpha Diagnostics |
100 ug |
EUR 164 |
-HRP conjugate (isotype control)) Goat IgG (fc)-HRP conjugate (isotype control) |
|
20011-Fc-HP |
Alpha Diagnostics |
100 ug |
EUR 164 |
 FC 131 |
|
B7647-1 |
ApexBio |
1 mg |
EUR 187 |
 Dkk-3 antibody |
|
22898-100ul |
SAB |
100ul |
EUR 390 |
Dog IgG (Fc) fragment (isotype control, non-immune), purified |
|
20016-3-FC |
Alpha Diagnostics |
0.5 mg |
EUR 250 |
 OPG-Fc Osteoprotegerin Human Recombinant Protein /Fc Chimera |
|
PROTO00300-1 |
BosterBio |
Regular: 50ug |
EUR 317 |
|
Description: Recombinant OPG produced in yeast contains 2x412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 109.6kDa. |
 Human CellExp? DKK-1, Human Recombinant |
|
7132-10 |
Biovision |
|
EUR 278 |
Human CellExp? DKK-1, Human Recombinant |
|
7132-50 |
Biovision |
|
EUR 1132 |
 ELISA kit for Human DKK-1 |
|
EK5390 |
SAB |
96 tests |
EUR 553 |
|
Description: Enzyme-linked immunosorbent assay kit for quantification of Human DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
 ELISA kit for Rat DKK-1 |
|
EK5668 |
SAB |
96 tests |
EUR 553 |
|
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DKK-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
 Human DKK-1 PicoKine ELISA Kit |
|
EK0867 |
BosterBio |
96 wells |
EUR 425 |
|
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
, purified) Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified |
|
20016-FC-B |
Alpha Diagnostics |
0.1 mg |
EUR 225 |
, purified) Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified |
|
20016-FC-F |
Alpha Diagnostics |
0.1 mg |
EUR 225 |
, purified) Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified |
|
20016-FC-HP |
Alpha Diagnostics |
0.1 mg |
EUR 225 |
 SCF-Fc |
|
E13-m004-1 |
EnoGene |
10μg |
EUR 343 |
) Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
|
CC49-10ug |
Novoprotein |
10ug |
EUR 156 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
|
CC49-1mg |
Novoprotein |
1mg |
EUR 2283 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
|
CC49-500ug |
Novoprotein |
500ug |
EUR 1613 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
|
CC49-50ug |
Novoprotein |
50ug |
EUR 369 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
 Dkk-3 Polyclonal Antibody |
|
ABP54542-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
Dkk-3 Polyclonal Antibody |
|
ABP54542-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
Dkk-3 Polyclonal Antibody |
|
ABP54542-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Dkk-3 from Human, Mouse. This Dkk-3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160 |
Dkk-3 Polyclonal Antibody |
|
ES5541-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Dkk-3 Polyclonal Antibody |
|
ES5541-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Dkk-3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
 Anti-Dkk-3 antibody |
|
STJ92720 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Dkk-3. |
Anti-Dkk-3 antibody |
|
STJ98001 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Dkk-3. |
 Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin)) Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin) |
|
20007-G3-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
) Human DKK-1 ELISA kit (4×96T) |
|
LF-EK50798 |
Abfrontier |
4×96T |
EUR 2201 |
 Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin)) Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin) |
|
20007-G1-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin)) Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin) |
|
20007-G2-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin)) Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin) |
|
20007-G4-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin)) Recombinant (HEK) Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin) |
|
20102-102-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin)) Recombinant (HEK) Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin) |
|
20102-103-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin)) Recombinant (HEK) Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin) |
|
20102-104-FC |
Alpha Diagnostics |
50 ug |
EUR 286 |
 SDF-1α-Fc |
|
E13-m001-1 |
EnoGene |
10μg |
EUR 291 |
 VEGF-121-Fc |
|
E13-m005-1 |
EnoGene |
10μg |
EUR 343 |
 VEGF-165-Fc |
|
E13-m006-1 |
EnoGene |
10μg |
EUR 343 |
 IL-2-Fc |
|
E13-m007-1 |
EnoGene |
10μg |
EUR 310 |
, Insect-10ug) Recombinant Human CD47 Protein, His-Fc (IgG), Insect-10ug |
|
QP11336-HIS-Fc-10ug |
EnQuireBio |
10ug |
EUR 201 |
 PinPoint-FC attP Placement Vector |
|
PIN300A-1 |
SBI |
10ug |
EUR 778 |
|
|
 Mouse IgG1-Fc (98-321aa, 102Cys/Ser, ~32 kda, His-tag, >95%, low endotoxin)) Recombinant (HEK) Mouse IgG1-Fc (98-321aa, 102Cys/Ser, ~32 kda, His-tag, >95%, low endotoxin) |
|
20102-101-FC |
Alpha Diagnostics |
50 |
EUR 286 |
 ELISA Kit) Human DKK-1(Dickkopf-related protein 1) ELISA Kit |
|
EH0113 |
FN Test |
96T |
EUR 524.1 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
 FLT4-Fc Vascular Endothelial Growth Factor Receptor-3 Fc Chimera Human Recombinant Protein |
|
PROTP35916-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
|
Description: Soluble FLT4 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a monomeric, glycosylated, polypeptide containing 774 amino acids and having a molecular mass of 260 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.;The FLT4 Fc Chimera is purified by proprietary chromatographic techniques. |
 Recombinant Human Dkk-3 Protein |
|
RP00355 |
Abclonal |
10 μg |
EUR 164 |
 : 96 Wells (OKAG00221)) Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221) |
|
OKAG00221 |
Aviva Systems Biology |
96 Wells |
EUR 596 |
|
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL |
 TNFRSF14 HVEM-Fc Human Recombinant Protein |
|
PROTO43557-1 |
BosterBio |
Regular: 100ug |
EUR 317 |
|
Description: TNFRSF14 Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide chain containing 396 amino acids and having a molecular mass of 58.0kDa. |
 Fc Protein) Recombinant Human FGFR1a (IIIc) Fc Protein |
|
PROTP11362-1 |
BosterBio |
50ug |
EUR 317 |
|
Description: The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous multiple forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant human FGFR1a (IIIc) is a 65.2 kDa protein containing 586 amino acids. Under reducing conditions, FGFR1a migrates between 100-110 kDa on SDS-PAGE gel. |
) Human EPOR / Erythropoietin Receptor Protein (Fc Tag) |
|
G1011-.1 |
ApexBio |
100 µg |
EUR 696 |
 [His]) Recombinant Dkk-1 Protein (Thr 32-His 266) [His] |
|
VAng-1453Lsx-100g |
Creative Biolabs |
100 µg |
EUR 1013 |
|
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1) |
Recombinant Dkk-1 Protein (Thr 32-His 266) [His] |
|
VAng-1453Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 4999 |
|
Description: Human Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1) |
 [Strep]) Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep] |
|
VAng-1454Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 6374 |
|
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1) |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep] |
|
VAng-1454Lsx-250g |
Creative Biolabs |
250 µg |
EUR 2470 |
|
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1) |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep] |
|
VAng-1454Lsx-25g |
Creative Biolabs |
25 µg |
EUR 765 |
|
Description: Human Dkk-1, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_036374.1) |
 [His]) Recombinant Dkk-1 Protein (Thr 32-His 272) [His] |
|
VAng-1455Lsx-500g |
Creative Biolabs |
500 µg |
EUR 4449 |
|
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908) |
Recombinant Dkk-1 Protein (Thr 32-His 272) [His] |
|
VAng-1455Lsx-50g |
Creative Biolabs |
50 µg |
EUR 1013 |
|
Description: Mouse Dkk-1, His tag, is expressed in HEK 293 cells. (Uniprot ID: O54908) |
 Human DKK-4 PicoKine ELISA Kit |
|
EK0868 |
BosterBio |
96 wells |
EUR 455 |
|
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA). |
 Human DKK-3 PicoKine ELISA Kit |
|
EK1323 |
BosterBio |
96 wells |
EUR 425 |
|
Description: For quantitative detection of human DKK-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
 (OKBB00603)) DKK-3 ELISA Kit (Human) (OKBB00603) |
|
OKBB00603 |
Aviva Systems Biology |
96 Wells |
EUR 505 |
|
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL |
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