Human top is a polygenic trait, influenced by a lot of genomic loci. In the pre-genomic period, top prediction was primarily based largely on parental top. More latest predictions of human top have made nice strides by integrating genotypic knowledge from massive biobanks with improved statistical methods. Nevertheless, latest research haven’t leveraged parental top, an added characteristic that we hypothesized would provide complementary predictive worth. In this examine, we assessed the predictive energy of polygenic threat scores (PRS) mixed with the conventional parental top predictors.
Our examine analyzed genotypic knowledge and parental top from 1,071 trios from the United Kingdom Biobank and 444 trios from the Framingham Heart Study. We explored a collection of statistical fashions to completely consider the efficiency of a number of PRS constructed along with parental data and proposed a mannequin we name PRS++ that features gender, parental top, and PRSs of oldsters and proband. Our estimate of top with an R 2 of ∼0.82 is, to our data, the most correct estimate but achieved for predicting human grownup top.
Without parental data, the R 2 from the greatest PRS-driven mannequin is ∼0.73. In abstract, utilizing grownup top prediction for example, we demonstrated that conventional predictors nonetheless play essential roles and benefit integration into the present traits of intensive PRS approaches.
Diet and common cognitive means in the UK Biobank dataset
Accumulating proof means that dietary interventions may need potential for use as a technique to guard towards age-related cognitive decline and neurodegeneration, as there are associations between some vitamins, meals teams, dietary patterns, and some domains of cognition. In this examine, we aimed to conduct the largest investigation of eating regimen and cognition up to now, by means of systematically inspecting the UK Biobank (UKB) knowledge to search out out whether or not dietary high quality and meals teams play a task on common cognitive means. This cross-sectional population-based examine concerned 48,749 contributors. UKB knowledge on meals frequency questionnaire and cognitive operate have been used.
Also, nutritious diet, partial fibre consumption, and milk consumption scores have been calculated. Adjusted fashions included age, intercourse, and BMI. We noticed associations between higher common cognitive means and greater intakes of fish, and unprocessed purple meat; and reasonable intakes of fibre, and milk. Surprisingly, we discovered that eating regimen high quality, vegetable consumption, excessive and low fibre and milk consumption have been inversely related to common cognitive means.
Our outcomes counsel that fish and unprocessed purple meat and/or vitamins which might be present in fish and unprocessed purple meat is perhaps helpful for common cognitive means. However, outcomes must be interpreted in warning as the identical meals teams might have an effect on different domains of cognition or psychological well being otherwise. These discrepancies in the present state of proof invitations additional analysis to look at domain-specific results of dietary patterns/meals teams on a variety of cognitive and affective outcomes with a particular focus on potential covariates that will have an effect on eating regimen and cognition relationship.
Can Blockchain Solve the Dilemma in the Ethics of Genomic Biobanks?
In discussions on the ethics of genome collections and biobanks, the fundamental fear about whether or not we’re permitted to gather and use people’ genomic and genetic knowledge is the potential for the violation of people’ proper to informational privateness. Yet, if we don’t allow these endeavors, we threat giving up on the future advantages of biomedical analysis. In this paper, I describe a personal enterprise in blockchain genomics that seeks to offer an apt resolution to issues about potential privateness violations in genome collections and biobanks. I
then present some causes to doubt the type of resolution to the dilemma that such start-ups suggest. I argue that the form of autonomy that grounds the worth of the proper to informational privateness can’t be secured with blockchain expertise alone. So, blockchain genomics ventures are inadequate to ascertain the permissibility of genome collections and biobanks.
I then focus on an extra moral problem to genomic biobanks. This problem takes the type of doubting that future advantages that consequence from biomedical analysis dependent on genomic databases will outweigh the prices. Despite criticisms of genomic analysis, I declare that it’s cheap to suppose that future web advantages can be gained from analysis on such databases. Therefore, I conclude that there stays a dilemma in the ethics of genomic biobanks.
Blood Pressure Determinants of Cerebral White Matter Hyperintensities and Microstructural Injury: UK Biobank Cohort Study
Small vessel illness and associated stroke and dementia dangers are linked to growing older and hypertension, however it’s unclear whether or not the pulsatile or regular blood stress (BP) part is extra essential for the growth of macrostructural hyperintensities and microstructural white matter injury. This was a cross-sectional evaluation of the UK Biobank cohort examine of community-based adults from 22 UK facilities. Linear associations have been decided between neuroimaging markers (white matter hyperintensity [WMH] quantity and diffusion imaging indices) and imply arterial stress and pulse stress (PP), each unadjusted and adjusted for age, intercourse, cardiovascular threat components, antihypertensive medicine, BP supply, and evaluation heart.
In 37 041 contributors aged 45 to 82 years (53% feminine), univariable analyses demonstrated that will increase in each BP elements have been related to better WMH quantity and white matter damage on diffusion indices, with a bigger impact for PP (standardized impact measurement for WMH: imply arterial BP: 0.182 [95% CIs, 0.170-0.193]; PP: 0.285 [95% CIs, 0.274-0.296]). In multivariable analyses, associations with imply arterial stress remained comparable, however associations with PP diminished, reflecting covariance with age and threat components (standardized impact measurement for WMH: imply arterial BP: 0.106 [95% CIs, 0.095-0.117]; PP: 0.011 [95% CIs, -0.001 to 0.023]).
Human Protein Wnt-3a (WNT3A) |
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| 1-CSB-EP026136HU | Cusabio |
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Description: Recombinant Human Protein Wnt-3a(WNT3A) expressed in E.coli |
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Mouse Protein Wnt-3a (Wnt3a) |
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| 1-CSB-EP026136MO | Cusabio |
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Description: Recombinant Mouse Protein Wnt-3a(Wnt3a) expressed in E.coli |
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Protein Wnt-3a Antibody (Biotin) |
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| 20-abx105841 | Abbexa |
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Protein Wnt-3a Antibody (FITC) |
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| 20-abx107257 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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| abx117009-100ug | Abbexa | 100 ug | 467 EUR |
Protein Wnt-3a Antibody (HRP) |
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| 20-abx108677 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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| 20-abx136135 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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| 20-abx000791 | Abbexa |
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Protein Wnt-3a (WNT3A) Antibody |
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| abx218011-100ug | Abbexa | 100 ug | 439 EUR |
Protein Wnt-3a (WNT3A) Antibody |
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| abx224220-100ug | Abbexa | 100 ug | 411 EUR |
Protein Wnt-3a Polyclonal Antibody |
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| 42596-100ul | SAB | 100ul | 333 EUR |
Wnt-C59 |
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| A8685-5 | ApexBio | 5 mg | 148 EUR |
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Description: Wnt-C59 is a selective inhibitor of Wnt signaling with IC50 value of 74 pM [1]. |
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Wnt Family Member 3A (WNT3A) Antibody |
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| 20-abx211813 | Abbexa |
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Wnt Family Member 3A (WNT3A) Antibody |
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| 20-abx211920 | Abbexa |
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Protein Wnt-3a Polyclonal Conjugated Antibody |
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| C42596 | SAB | 100ul | 397 EUR |
Wnt Antagonist, C59 |
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| 2063-5 | Biovision | 359 EUR | |
Human Protein Wnt-3a(WNT3A) ELISA kit |
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| CSB-EL026136HU-24T | Cusabio | 1 plate of 24 wells | 165 EUR |
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Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a (WNT3A) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Protein Wnt-3a(WNT3A) ELISA kit |
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| 1-CSB-EL026136HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Protein Wnt-3a(WNT3A) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Mouse Protein Wnt-3a(WNT3A) ELISA kit |
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| CSB-EL026136MO-24T | Cusabio | 1 plate of 24 wells | 165 EUR |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a (WNT3A) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Mouse Protein Wnt-3a(WNT3A) ELISA kit |
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| 1-CSB-EL026136MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Protein Wnt-3a(WNT3A) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human WNT3A/ Protein Wnt-3a ELISA Kit |
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| E2688Hu | Sunlong | 1 Kit | 571 EUR |
Mouse Wnt3a/ Protein Wnt-3a ELISA Kit |
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| E1594Mo | Sunlong | 1 Kit | 571 EUR |
Human Protein Wnt-3a (WNT3A) ELISA Kit |
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| abx570841-96tests | Abbexa | 96 tests | 668 EUR |
Mouse Protein Wnt-3a (WNT3A) ELISA Kit |
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| abx575000-96tests | Abbexa | 96 tests | 668 EUR |
Chicken Protein Wnt-3a (WNT3A) ELISA Kit |
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| abx519656-96tests | Abbexa | 96 tests | 911 EUR |
Human Protein Wnt-3a (WNT3A) ELISA Kit |
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| abx251482-96tests | Abbexa | 96 tests | 746 EUR |
Mouse Protein Wnt-3a (WNT3A) ELISA Kit |
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| abx255085-96tests | Abbexa | 96 tests | 746 EUR |
ELISA kit for Mouse Protein Wnt-3a |
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| EK4364 | SAB | 96 tests | 553 EUR |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids. |
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ELISA kit for Human Protein Wnt-3a |
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| EK4365 | SAB | 96 tests | 553 EUR |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human Protein Wnt-3a in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Mouse Wnt3a(Protein Wnt-3a) ELISA Kit |
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| EM0737 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml |
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Human WNT3A(Protein Wnt-3a) ELISA Kit |
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| EH2146 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml |
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Mouse Protein Wnt- 3a, Wnt3a ELISA KIT |
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| ELI-06995m | Lifescience Market | 96 Tests | 865 EUR |
Chicken Protein Wnt- 3a, WNT3A ELISA KIT |
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| ELI-06996c | Lifescience Market | 96 Tests | 928 EUR |
Human Protein Wnt- 3a, WNT3A ELISA KIT |
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| ELI-06997h | Lifescience Market | 96 Tests | 824 EUR |
5-HT-3A Antibody |
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| 34152-100ul | SAB | 100ul | 252 EUR |
5-HT-3A Antibody |
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| 34152-50ul | SAB | 50ul | 187 EUR |
5-HT-3A Antibody |
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| DF3502 | Affbiotech | 200ul | 304 EUR |
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Description: 5-HT-3A Antibody detects endogenous levels of total 5-HT-3A. |
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5- HT- 3A Antibody |
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| ABD3502 | Lifescience Market | 100 ug | 438 EUR |
Growth Factor Set IV, StemBoost? |
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| K426-5 | Biovision | 854 EUR | |
ELISA kit for Mouse Protein Wnt-3a (WNT3A) |
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| KTE70008-48T | Abbkine | 48T | 332 EUR |
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Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Mouse Protein Wnt-3a (WNT3A) |
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| KTE70008-5platesof96wells | Abbkine | 5 plates of 96 wells | 2115 EUR |
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Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Mouse Protein Wnt-3a (WNT3A) |
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| KTE70008-96T | Abbkine | 96T | 539 EUR |
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Description: Quantitative sandwich ELISA for measuring Mouse Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Protein Wnt-3a (WNT3A) |
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| KTE60023-48T | Abbkine | 48T | 354 EUR |
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Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Protein Wnt-3a (WNT3A) |
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| KTE60023-5platesof96wells | Abbkine | 5 plates of 96 wells | 2252 EUR |
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Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Protein Wnt-3a (WNT3A) |
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| KTE60023-96T | Abbkine | 96T | 572 EUR |
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Description: Quantitative sandwich ELISA for measuring Human Protein Wnt-3a (WNT3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Human Growth Differentiation Factor 5 (GDF-5) Antibody |
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| 30011-05111 | AssayPro | 150 ug | 261 EUR |
Recombinant Fibroblast Growth Factor 5 (FGF5) |
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| 4-RPA357Hu01 | Cloud-Clone |
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Description: Recombinant Human Fibroblast Growth Factor 5 expressed in: E.coli |
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Recombinant Growth Differentiation Factor 5 (GDF5) |
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| 4-RPC110Hu01 | Cloud-Clone |
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Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli |
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Recombinant Growth Differentiation Factor 5 (GDF5) |
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| 4-RPC110Hu02 | Cloud-Clone |
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Description: Recombinant Human Growth Differentiation Factor 5 expressed in: E.coli |
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Recombinant Growth Differentiation Factor 5 (GDF5) |
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| 4-RPC110Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Growth Differentiation Factor 5 expressed in: E.coli |
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Mouse Growth/differentiation factor 5 (Gdf5) |
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| 1-CSB-EP009349MO | Cusabio |
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Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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| 20-abx128010 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx128606 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx109840 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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| 20-abx123595 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx320075 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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| 20-abx323550 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx103263 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx103264 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx006710 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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| 20-abx009268 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| abx026572-400ul | Abbexa | 400 ul | 523 EUR |
Growth Differentiation Factor 5 (GDF5) Antibody |
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| abx026572-80l | Abbexa | 80 µl | 286 EUR |
Growth Differentiation Factor 5 (GDF5) Antibody |
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| abx031516-400ul | Abbexa | 400 ul | 523 EUR |
Growth Differentiation Factor 5 (GDF5) Antibody |
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| abx031516-80l | Abbexa | 80 µl | 286 EUR |
Growth Differentiation Factor 5 (GDF5) Antibody |
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| abx432738-200ul | Abbexa | 200 ul | 286 EUR |
Fibroblast Growth Factor 5 (FGF5) Antibody |
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| abx233094-100ug | Abbexa | 100 ug | 509 EUR |
Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx176717 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx176718 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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| 20-abx172410 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx172684 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx172685 | Abbexa |
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Growth Differentiation Factor 5 (GDF5) Antibody |
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| 20-abx327566 | Abbexa |
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Growth/differentiation factor 5 Polyclonal Antibody |
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| 42178-100ul | SAB | 100ul | 333 EUR |
Epidermal Growth Factor (EGF), human recombinant |
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| P1008-.5 | ApexBio | 500 µg | 313 EUR |
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Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR. |
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Epidermal Growth Factor (EGF), human recombinant |
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| P1008-5 | ApexBio | 5 mg | 1372 EUR |
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Description: Human epidermal growth factor (EGF) is a member of the EGF-family and plays an important role in the regulation of cell growth, proliferation, and differentiation through binding to its receptor EGFR. |
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5-Hydroxytryptamine Receptor 3A (5-HT3A) Antibody |
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| 20-abx013887 | Abbexa |
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Wnt3a ELISA Kit| Mouse Protein Wnt-3a ELISA Kit |
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| EF013348 | Lifescience Market | 96 Tests | 689 EUR |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-100ug |
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| QP8838-ec-100ug | EnQuireBio | 100ug | 408 EUR |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-10ug |
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| QP8838-ec-10ug | EnQuireBio | 10ug | 200 EUR |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-1mg |
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| QP8838-ec-1mg | EnQuireBio | 1mg | 1632 EUR |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-200ug |
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| QP8838-ec-200ug | EnQuireBio | 200ug | 634 EUR |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-500ug |
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| QP8838-ec-500ug | EnQuireBio | 500ug | 1060 EUR |
Recombinant Human Protein Wnt-3a Protein, His, E.coli-50ug |
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| QP8838-ec-50ug | EnQuireBio | 50ug | 263 EUR |
Fetal Bovine Serum,Low IgG , < 5 ug/ml |
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| F0710-050 | GenDepot | 500 ml | 1198 EUR |
5-HT-3A Conjugated Antibody |
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| C34152 | SAB | 100ul | 397 EUR |
5-HT-3A Blocking Peptide |
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| DF3502-BP | Affbiotech | 1mg | 195 EUR |
Epidermal Growth Factor Receptor Peptide (985-996) |
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| 5-01114 | CHI Scientific | 4 x 1mg | Ask for price |
Insulin-like Growth Factor I (57-70) |
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| 5-01399 | CHI Scientific | 4 x 5mg | Ask for price |
Insulin-Like Growth Factor II (69-84) |
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| 5-01400 | CHI Scientific | 4 x 1mg | Ask for price |
Platelet-Derived Growth Factor Receptor Substrate 2 |
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| 5-01775 | CHI Scientific | 4 x 1mg | Ask for price |
Prepro-Nerve Growth Factor (99-115) (mouse) |
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| 5-01801 | CHI Scientific | 4 x 1mg | Ask for price |
The synergistic interplay between PP and age elevated the impact of age on WMH and diffusion indices. Both macrostructural and microstructural white matter damage had comparable associations with the pulsatile and regular elements of hypertension, though PP accentuated the relationship between age and white matter injury.